By National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Super damaging ingredients (EHSs)² may be published by accident due to chemical spills, business explosions, fires, or injuries concerning railroad vehicles and vans transporting EHSs. employees and citizens in groups surrounding business amenities the place EHSs are synthetic, used, or kept and in groups alongside the nation's railways and highways are probably vulnerable to being uncovered to airborne EHSs in the course of unintended releases or intentional releases by means of terrorists. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental safety company (EPA) has pointed out nearly four hundred EHSs at the foundation of acute lethality facts in rodents. As a part of its efforts to improve acute publicity instruction degrees for EHSs, EPA and the business enterprise for poisonous components and ailment Registry (ATSDR) in 1991 asked that the nationwide study Council (NRC) enhance guidance for constructing such degrees. according to that request, the NRC released guidance for constructing group Emergency publicity degrees for detrimental components in 1993. as a result, average working strategies for constructing Acute publicity instruction degrees for detrimental ingredients was once released in 2001, supplying up-to-date techniques, methodologies, and different instructions utilized by the nationwide Advisory Committee (NAC) on Acute publicity instruction degrees for harmful ingredients and the Committee on Acute publicity guide degrees (AEGLs) in constructing the AEGL values. In 1998, EPA and DOD asked that the NRC independently assessment the AEGLs constructed by means of NAC. according to that request, the NRC geared up inside its Committee on Toxicology (COT) the Committee on Acute publicity instruction degrees, which ready this file. Acute publicity guide degrees for chosen Airborne chemical compounds is the 10th quantity of the sequence and files for N,N-dimethylformamide, jet propellant fuels five and eight, methyl ethyl ketone, perchloromethyl mercaptan, phosphorus oxychloride, phosphorus trichloride, and sulfuryl chloride.
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Developmental effects included reduced fetal weight; increases in the litter incidence of total external, skeletal, and visceral malformations and skeletal variations; and increased number and percentage of dead implants (BASF 1974a,b,c; Kimmerle and Machemer 1975; BASF 1989; Hellwig et al. 1991; Lewis et al. 1992). Genotoxicity testing of DMF has generally been negative (Antoine et al. 1983; NTP 1992). I. Dupont de Nemours & Co. 1992); a more recent study found that chronically inhaled DMF produced hepatocellular adenomas and carcinomas in rats at 400 ppm or 800 ppm, respectively, and hepatoblastomas and hepatocellular adenomas and carcinomas in mice at 200 ppm and above (Senoh et al.
1988). A total of 58 workers participated in the study: All had at least one liver function test; 46 completed a questionnaire addressing demographic background, job history, and symptoms; and 27 underwent an extensive clinical evaluations to assess liver function. Workers were exposed to DMF in the process of coating fabric in poorly ventilated areas, and little effort was made to control direct skin contact with the solvent. Results from the questionnaire and clinic interviews revealed complaints of gastrointestinal problems (31 of 46), headache and dizziness (18 of 46), and alcohol intolerance characterized by facial flushing and palpitations after drinking ethanol (11 of 46; total number consuming ethanol not provided).
Dupont de Nemours & Co. 1992); a more recent study found that chronically inhaled DMF produced hepatocellular adenomas and carcinomas in rats at 400 ppm or 800 ppm, respectively, and hepatoblastomas and hepatocellular adenomas and carcinomas in mice at 200 ppm and above (Senoh et al. 2004). An AEGL-1 value was not recommended because data pertaining to end points relevant to the AEGL-1 definition were not available. The AEGL-2 derivation was based on the study in which groups of 15 pregnant Himalayan rabbits were exposed to DMF at 0, 50, 150, or 450 ppm for 6 h/day on gestation days (GD) 7-19 (Hellwig et al.
Acute Exposure Guideline Levels for Selected Airborne Chemicals by National Research Council, Division on Engineering and Physical Sciences, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels