By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This e-book is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and comprises AEGLs for chemical compounds corresponding to ammonia, nickel carbonyl and phosphine, between others.
At the request of the dept of protection, the nationwide learn Council has reviewed the correct medical literature compiled via a professional panel and proven Acute publicity guide degrees (AEGLs) for 12 new chemical compounds. AEGLs characterize publicity degrees lower than which hostile healthiness results are usually not more likely to take place and are worthwhile in responding to emergencies equivalent to unintended or intentional chemical releases in the neighborhood, the place of work, transportation, the army, and for the remediation of infected sites.
Three AEGLs are licensed for every chemical, representing publicity degrees that lead to: 1) impressive yet reversible soreness; 2) long-lasting health and wellbeing results; and three) life-threatening future health impacts.
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Additional info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
1960), which was used to derive AEGL-1 values. 5-10 ppm allylamine had slight to moderate eye and nose irritation and pulmonary discomfort, whereas at the next higher concentration tested, ~14 ppm, exposure was “intolerable” (extreme pulmonary discomfort and irritation of the eyes, nose, and throat) and was almost immediately terminated. 2. Summary of Animal Data Relevant to AEGL-2 The only relevant single-exposure study evaluated male Long-Evans rats exposed to 20-100 ppm for 4-48 h and examined histologically 8 h to 14 days after the start of exposure (Guzman et al.
1960). All treated rats showed signs of eye and respiratory tract irritation, and some had lacrimation and red nasal discharge. Rats that died had stomachs distended with air, fluid-filled lungs, alveolar hemorrhage, and pulmonary edema. The NOEL for lethality, as represented by LC01 (1% lethality) values calculated using probit analysis, was the AEGL-3 end point. The 1-h, 4-h, and 8-h AEGLs were obtained using the respective LC01 values. LC50 data. An uncertainty factor of 30 was applied: 10 to account for interspecies variability (lack of acute toxicity studies from other species with AEGL-3 level end points) and 3 for human variability (the steep dose-response (~2-fold increase in concentration caused mortality to increase from 0 to 100%) indicates that the NOEL for lethality due to direct destruction of lung tissue is not likely to vary greatly among humans).
1-1,000 µg/mL allylamine, with or without Aroclor-induced rat or hamster liver S9. 6. Carcinogenicity No studies on the carcinogenicity of allylamine in animals were located. Neither EPA nor IARC has classified allylamine as to carcinogenicity. The allylamine metabolite acrolein EPA weight-of-evidence characterization, under the 1999 Draft Revised Guidelines for Carcinogen Risk Assessment, is that the potential carcinogenicity of acrolein cannot be determined because the existing “data are inadequate for an assessment of human carcinogenic potential for either the oral or inhalation route of exposure” (EPA 2004).
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 by National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels