By Lorenzo Tomatis (auth.), Lorenzo Tomatis (eds.)
Air pollutants and Human Cancer analyzes the facts for the potential contribution of pollution to the foundation of human melanoma. exceptional specialists in a variety of parts of melanoma study file on: - pollution and melanoma: an outdated and a brand new challenge; - assets, nature and degrees of air toxins; - size and tracking of person exposures; - experimental facts for the carcinogenicity of air toxins; - epidemiological facts on pollution and melanoma; - melanoma possibility estimation and prevention.
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Swedish data represent a random sample of the total population in Stockholm. 1) only 2 female smokers; 2) no female smokers. Reproduced with permission from ref. 0 Fig. 5. Concentrations of cadmium in blood (median values) for male (M) and female (F) teachers, subdivided into smokers and nonsmokers (including former smokers). Indian data represent teachers in Ahmedabad. Swedish data represent a random sample of the total population in Stockholm. , half the detection limit. Reproduced with permission from ref.
In wells drilled into rock, radium and radon concentrations in the water may be high. When this water is used in households, radon is released into indoor air and causes an increase in the average radon concentration. 1 Bq/l in water from wells drilled in rock of high radium content, as in Maine and Iowa (USA), Scandinavia and Finland . In Europe and North America, the mean radon daughter concentrations range between 10 and 50 Bq/m 3 , with the highest averages reported in Scandinavia .
DNA-adducts, mechanistically related to the initiation events of cancer, give a measure of the target dose. However, in most cases true target tissues cannot be obtained and therefore surrogate tissues, such as white blood cells, are being used. Protein binding is usually measured from haemoglobin or plasma protein . Table 2 lists the protein-binding studies where exposure levels have been quantitated in humans. Similarly, DNA-binding studies are listed in Table 3; the tissues analysed were in most cases white blood cells or lymphocytes [21,28].
Air Pollution and Human Cancer by Lorenzo Tomatis (auth.), Lorenzo Tomatis (eds.)